CV-19 therapeutic drug trials

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Jersey Girl
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Re: CV-19 therapeutic drug trials

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EAllusion I hope you listen to the senate hearings. Trump's going to go off on a tear over the testimonies.

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Res Ipsa
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Re: CV-19 therapeutic drug trials

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Yeah, that and long term effects of organ damage.

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Re: CV-19 therapeutic drug trials

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[quote="Jersey Girl" post_id=1224338 time=1589296021 user_id=16]
EAllusion I hope you listen to the senate hearings. Trump's going to go off on a tear over the testimonies.
[/quote]

Paying attention to the Supreme Court right now. It is, as expected, bad. Very bad.

I saw in an alert that Dr. Fauci acknowledged that there are meaningfully more deaths than the official tally of 80,000ish. I think that's the first time I've seen a Trump admin official on the record stating that.

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Re: CV-19 therapeutic drug trials

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EAllusion wrote:
Tue May 12, 2020 9:42 am
Jersey Girl wrote:
Tue May 12, 2020 9:07 am
EAllusion I hope you listen to the senate hearings. Trump's going to go off on a tear over the testimonies.
Paying attention to the Supreme Court right now. It is, as expected, bad. Very bad.

I saw in an alert that Dr. Fauci acknowledged that there are meaningfully more deaths than the official tally of 80,000ish. I think that's the first time I've seen a Trump admin official on the record stating that.
https://www.huffpost.com/entry/fauci-qu ... 6136eb06a1

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Doctor CamNC4Me
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Re: CV-19 therapeutic drug trials

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EAllusion: I saw in an alert that Dr. Fauci acknowledged that there are meaningfully more deaths than the official tally of 80,000ish. I think that's the first time I've seen a Trump admin official on the record stating that.

CONSPIRACY ALERT! CONSPIRACY ALERT!

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Jersey Girl
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Re: CV-19 therapeutic drug trials

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We have got us some Remdesivir. Not much. But we've got it!

Experimental coronavirus drug remdesivir being distributed in Colorado
https://www.denverpost.com/2020/05/13/e ... -colorado/

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Re: CV-19 therapeutic drug trials

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Gunnar
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Re: CV-19 therapeutic drug trials

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Jersey Girl wrote:
Wed May 13, 2020 10:20 pm
We have got us some Remdesivir. Not much. But we've got it!

Experimental coronavirus drug remdesivir being distributed in Colorado
https://www.denverpost.com/2020/05/13/e ... -colorado/
I'm glad that they discovered a drug that helps, even though Remdesivir's effectiveness is somewhat limited. I hope they find something more effective than that. There are some other drugs now in clinical trials that may turn out to be more promising than Remdesivir.

Ultimately the best solution, when finally available, will probably be a vaccine. Have you heard of this promising vaccine approach?
UPMC and University of Pittsburgh School of Medicine Scientists Announce Potential Vaccine. Be sure to watch the accompanying video!
Scientists at UPMC and the University of Pittsburgh School of Medicine have announced a potential vaccine against SARS-CoV-2, the new coronavirus causing the COVID-19 pandemic.

When tested in mice, the vaccine produces antibodies specific to SARS-CoV-2 at quantities thought to be enough to neutralize the virus.

The vaccine is delivered through a fingertip-sized skin patch. The research team calls this vaccine PittCoVacc, short for Pittsburgh Coronavirus Vaccine.

A paper on the vaccine appeared April 2 in EBioMedicine, which is published by The Lancet. It is the first study on a potential COVID-19 vaccine to be published after a critique from fellow scientists at outside institutions.

UPMC and University of Pittsburgh School of Medicine researchers were able to act quickly because they laid the groundwork during earlier coronavirus epidemics.

Scientists also use a new approach to deliver the drug, called a microneedle array, to increase potency. This array is a fingertip-sized patch of 400 tiny needles that deliver spike protein pieces into the skin, where the immune reaction is the strongest.

The patch goes on like a Band-Aid, and the needles, which are made entirely of sugar and protein pieces, simply dissolve into the skin.
This type of vaccine, according to the UPMC researchers, can be easily and cheaply scaled up to mass production and distribution. It doesn't need refrigeration for either transport or storage, and can be stored indefinitely at room temperature until needed.

Additionally, this vaccination technique can be adapted for applying any kind of vaccine, not just corona virus, including the common flu. They have applied for approval for human trials, which will hopefully be approved and started soon. I fervently hope this works out as well as anticipated and becomes widely available. Imagine! Never having to endure a needle to get vaccinated again, for anything! I can hardly wait for this to become widely available for all routine vaccinations -- not just covid-19!

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Re: CV-19 therapeutic drug trials

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No, Gunnar, I don't believe I've heard about that particular vaccine development. I think our best and most immediate solution to fight this virus besides continuing social distancing, masking, staying at home, and continued efforts to develop a viable vaccine is convalescent plasma.

I don't worry about needles. I've been shot up so many times in my life I'm completely numb to it.

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Re: CV-19 therapeutic drug trials

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Today. Here's the doctor whose videos prompted the OP. He's still talking about ACE2 receptors being the portals of entry.

There's autopsy photos in this. If you can't handle it, pass it up.

12 Autopsy Cases Reveal TRUTH About How Patients Die From Coronavirus (COVID-19)
https://www.youtube.com/watch?v=y6h8TIx ... dex=7&t=0s

Here's the study he references. https://www.acpjournals.org/doi/10.7326/M20-2003

I mentioned previously that I take one of the medications that is being trialed as a therapeutic for CV-10, Lisinopril. This doctor actually ranked the ACE2 inhibitor Lorsartan higher than Lisinopril in it's expected ability to thwart the virus and the cytokine storm that spells doom for many patients. On account of an unwanted side effect, I'll be on Losartan probably by Monday or as soon as I get the guts up to make the switch because I already have it.

I don't know which one of these meds will come to the forefront as a good therapeutic for the virus. I don't think it's a bad idea for older folks or those with various conditions to be taking low dose aspirin right now if they're not on an anticoagulant to fend off the deadly blood clots that were found in the autopsies. Otherwise for those who have the significant conditions that complicate the virus, I say keep everything in check as best as we can and carry on.

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Re: CV-19 therapeutic drug trials

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Jersey Girl wrote:
Fri May 15, 2020 12:36 am
No, Gunnar, I don't believe I've heard about that particular vaccine development. I think our best and most immediate solution to fight this virus besides continuing social distancing, masking, staying at home, and continued efforts to develop a viable vaccine is convalescent plasma.

I don't worry about needles. I've been shot up so many times in my life I'm completely numb to it.
Needles don't particularly bother me or stress me out either, but there are many people who have a strong aversion to them. Such people would welcome and would be less likely to resist admonitions to get vaccinated if this technique was a readily available alternative to needles. Besides that, according the researchers developing it, this micro needle patch technique administers the vaccine precisely to the layer of skin which is the body's first line of defense against invading pathogens, and thus requires smaller quantities of the vaccine to be fully effective. An even bigger plus is that because these patches are dry and do not require the vaccine to be suspended in an aqueous solution, they need not be refrigerated and can be stored indefinitely at room temperature. This greatly reduces the cost of transporting the vaccine and the difficulty of keeping sufficient quantities on hand and viable in storage until it is needed.

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Re: CV-19 therapeutic drug trials

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WTAF

This is the man who is willing/planning to fork out the money for factories in advance of the development of a vaccine to meet the needs of this country upon roll out. He's taking care of his damn state's testing needs and they shut him down? For what purpose?

FDA halts Bill Gates coronavirus testing program

https://thehill.com/policy/healthcare/4 ... LRdpMS077I

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Re: CV-19 therapeutic drug trials

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Jersey Girl wrote:
Sat May 16, 2020 4:04 pm
WTAF

This is the man who is willing/planning to fork out the money for factories in advance of the development of a vaccine to meet the needs of this country upon roll out. He's taking care of his damn state's testing needs and they shut him down? For what purpose?

FDA halts Bill Gates coronavirus testing program

https://thehill.com/policy/healthcare/4 ... LRdpMS077I
I'm sure you know why, or at least have a strong hunch. Trump has made it abundantly clear that he perceives any increases in the number of confirmed coronavirus cases as a threat to his approval rating and his chances of being reelected. He desperately does NOT want to find out that the actual number of covid-19 cases is several times higher that what is currently being reported.

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Re: CV-19 therapeutic drug trials

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Gunnar wrote:
Sat May 16, 2020 5:02 pm
Jersey Girl wrote:
Sat May 16, 2020 4:04 pm
WTAF

This is the man who is willing/planning to fork out the money for factories in advance of the development of a vaccine to meet the needs of this country upon roll out. He's taking care of his damn state's testing needs and they shut him down? For what purpose?

FDA halts Bill Gates coronavirus testing program

https://thehill.com/policy/healthcare/4 ... LRdpMS077I
I'm sure you know why, or at least have a strong hunch. Trump has made it abundantly clear that he perceives any increases in the number of confirmed coronavirus cases as a threat to his approval rating and his chances of being reelected. He desperately does NOT want to find out that the actual number of covid-19 cases is several times higher that what is currently being reported.
That's not the only thing that crossed my mind, Gunnar. I listened to interviews with Gates and as part of his goal of building factories to manufacture and distribute a vaccine (or vaccines) he pledged to stock them with syringes, vials, etc. Which is exactly what was just announced yesterday (?) by the administration to prepare for the delivery of a vaccine to the country.

He's totally trying to usurp the totality Gates' efforts and why? Because he doesn't want anyone to steal his self perceived thunder.

Anyone with half a brain who is watching all of this mess can easily see it's all about him grabbing headlines for re-election. Because, if he gave a damn about the American public he would've heeded the early warnings, geared up to meet our PPE and critical equipment needs, he would have used the Defense Production Act to ramp up production of both PPE/Equipment, he wouldn't have spit in the face of the states and their governors, he would have followed the CDA guidelines for re-opening instead of tossing them in the waste basket, he wouldn't have had the CDA water down their re-opening guidelines causing even more confusion and chaos, and he wouldn't be promoting re-opening the states to jump start the economy or cheering on protesters in a country where we don't even have the PPE for medical personnel much less can the every day Joe acquire any of it for the grandiose transition to greatness. :rolleyes:

This guy can just straight up kiss my ass. He's a liar, he's corrupt, he's a game player, he hasn't got the intellect abilities of a second grader, and he's effectively slaughtering American citizens so that HE can win. Not this country.

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Re: CV-19 therapeutic drug trials

Post by Gunnar »

Jersey Girl wrote:
Sat May 16, 2020 5:39 pm
That's not the only thing that crossed my mind, Gunnar. I listened to interviews with Gates and as part of his goal of building factories to manufacture and distribute a vaccine (or vaccines) he pledged to stock them with syringes, vials, etc. Which is exactly what was just announced yesterday (?) by the administration to prepare for the delivery of a vaccine to the country.

He's totally trying to usurp the totality Gates' efforts and why? Because he doesn't want anyone to steal his self perceived thunder.

Anyone with half a brain who is watching all of this mess can easily see it's all about him grabbing headlines for re-election. Because, if he gave a damn about the American public he would've heeded the early warnings, geared up to meet our PPE and critical equipment needs, he would have used the Defense Production Act to ramp up production of both PPE/Equipment, he wouldn't have spit in the face of the states and their governors, he would have followed the CDA guidelines for re-opening instead of tossing them in the waste basket, he wouldn't have had the CDA water down their re-opening guidelines causing even more confusion and chaos, and he wouldn't be promoting re-opening the states to jump start the economy or cheering on protesters in a country where we don't even have the PPE for medical personnel much less can the every day Joe acquire any of it for the grandiose transition to greatness. :rolleyes:

This guy can just straight up kiss my ass. He's a liar, he's corrupt, he's a game player, he hasn't got the intellect abilities of a second grader, and he's effectively slaughtering American citizens so that HE can win. Not this country.
Yeah, all that too, Jersey Girl. That goes almost without saying. :smile:

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